ScreenBEAM2
Gene-level meta-analysis of high-throughput functional genomics screens
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Overview
ScreenBEAM2 is the upgraded version of ScreenBEAM1. It can perform functional genomics screening from FASTQ file. It is a trim-free, allowing number of mismatch, BLAT-dependent pipeline. Downstream analysis uses Bayesian hierarchical modeling, removed bias caused by the unbalanced number of sh/sgRNA targeting the same gene.
Citing ScreenBEAM2
If ScreenBEAM2 is useful to your work, please cite the following paper: Yu J, Silva, J, Califano A. ScreenBEAM: a Novel Meta-Analysis Algorithm for Functional Genomics Screens via Bayesian Hierarchical Modeling. _Bioinformatics, 2015 Sep 28. pii: btv556.
Contact
The ScreenBEAM2 software is developed by Yu Lab at St. Jude Children’s Research Hospital.
We’re very interested to hear feedback about using ScreenBEAM2 in your analysis. If you find any issues/bugs, or have any suggestions, please don’t hesitate to create issues in GitHub, or contact us directly.